The Spiral Skein may refer to a number of locations, mostly relating to the realm of Mephala.
- The Spiral Skein (Summerset), a part of the realm visited during the Summerset story quest The Dreaming Cave
- The Spiral Skein (Through a Veil Darkly), a part of the realm visited during the Summerset prologue quest Through a Veil Darkly
- Spiral Shadows, the sixth round of the Maelstrom Arena, based on the realm
- Cradle of Shadows, a dungeon which merges into the realm
- Crystal Tower, a tower present in every plane which merges into the realm at certain areas
- Doomvault Porcixid, a delve which merges into the realm at certain areas
- The Spiral Skein zone, which was planned as a DLC but ultimately scrapped
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